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Iridium-Catalyzed Enantioselective Hydrogenation of Quinoline Derivatives
F.-R. Gou, W. Li, X. Zhang*, Y.-M. Liang*
Rutgers, The State University of New Jersey, Piscataway and The Pennsylvania State University, University Park, USA; Lanzhou University, P. R. of China
21 December 2010 (online)
This paper describes an efficient hydrogenation procedure to afford enantioenriched hydrogenated quinoline derivatives. The same catalyst is also capable for the hydrogenation of quinoline N-oxide, although the conversion and enantioselectivity still need to be improved.