Synfacts 2011(1): 0058-0058  
DOI: 10.1055/s-0030-1259165
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed 1,4-Hydroboration of Coumarins with Pinacolborane

Contributor(s): Hisashi Yamamoto, Jiajing Tan
H. Kim, J. Yun*
Sungkyunkwan University, Suwon, South Korea
Further Information

Publication History

Publication Date:
21 December 2010 (online)

Significance

In this communication, the authors reported a highly enantioselective synthesis of dihydrocoumarins derivatives by copper-catalyzed asymmetric 1,4-hydroboration of coumarins with pinacolborane and subsequent reaction with electrophiles. The synthetic application was demonstrated in the formal synthesis of biologically active molecules.