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Asymmetric Propargylation of Benzaldehydes
D. L. Usanov, H. Yamamoto*
The University of Chicago, USA
21 December 2010 (online)
The catalytic asymmetric Nozaki-Hiyama (NH) reaction provides direct access to useful chiral alcohols. Utilizing a novel chiral chromium catalyst, the authors report an efficient enantioselective propargylation of benzaldehyde derivatives, providing chiral homopropargyl alcohols with good yields and enantioselectivities.