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Substrate-Binding Phosphine Ligand in Enantioselective Hydroformylation
A. D. Worthy, C. L. Joe, T. E. Lightburn, K. L. Tan*
Boston College, Chestnut Hill, USA
21 December 2010 (online)
The authors report an enantioselective hydroformylation of allylic amines using a tricyclic ligand. The strategy of using a catalytic ligand to bind both the substrate and the transition-metal catalyst has only recently been employed by the authors (J. Am. Chem. Soc. 2008, 130, 9210) as well as by the Breit group (e.g., Angew. Chem. Int. Ed. 2008, 47, 7346). The main benefits of this strategy versus alternative enantioselective rhodium-catalyzed hydroformylations are the higher regioselectivity and reactivity under milder conditions.