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Acylsilanes as Pronucleophiles in Palladium-Catalyzed Asymmetric Allylic Alkylation
J.-P. Chen, C.-H. Ding, W. Liu, X.-L. Hou*, L.-X. Dai
Shanghai Institute of Organic Chemistry, P. R. of China
21 December 2010 (online)
It remains a great challenge to install two stereocenters by palladium-catalyzed asymmetric allylic alkylation (Pd-AAA). The authors report that acylsilanes can engage in highly regio- and stereoselective reactions with allyl carbonates under Pd-AAA. The authors go on to demonstrate the power of this methodology in the synthesis of two interesting targets.