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NHC-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes
S. De Sarkar, A. Studer*
Westfälische Wilhelms-Universität Münster, Germany
21 December 2010 (online)
Using carbene catalysis and an oxidant, α,β-unsaturated aldehydes can be activated towards Michael addition via a double umpolung process. Various β-dicarbonyl compounds 3 undergo conjugate addition to enals 2 to afford dihydropyranones 4 in good yields.