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Synlett 2011(3): 289-293  
DOI: 10.1055/s-0030-1259333
SYNPACTS
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Monofluoroalkenes via the Activation of Allylic C-F Bonds: A Novel Route to β-Aminofluoroalkenes Using Pd-Catalyzed Allylic Amination Reactions of 3,3-Difluoropropenes

Jean-François Paquin*
Canada Research Chair in Organic and Medicinal Chemistry, Département de Chimie, Université Laval, 1045 Avenue de la Médecine, Québec, QC, G1V 0A6, Canada
Fax: +1(418)6567916; e-Mail: jean-francois.paquin@chm.ulaval.ca;
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Publication History

Received 10 November 2010
Publication Date:
25 January 2011 (online)

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Abstract

This article portrays the development of a novel and efficient synthetic route to β-aminofluoroalkenes, from readily available 3,3-difluoropropenes and amines, that proceeds via the activation of an allylic C-F bond.

Key words

C-F activation - organofluorine chemistry - fluoroal­kenes - palladium - homogeneous catalysis

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