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One-Pot Synthesis of 1,2,3-Triazoles by Copper and Palladium Catalysis
J. Panteleev, K. Geyer, A. Aguilar-Aguilar, L. Wang, M. Lautens*
University of Toronto, Canada
16 February 2011 (online)
A combination of copper(I)-catalyzed azide-alkyne cycloaddition and palladium-catalyzed C-H bond functionalization gives a highly modular approach to fused 1,2,3-triazoles. Functionalized pyrroles, furans, thiophenes, and even benzene derivatives are viable in this route, affording the fused polycycles in high yields.