Synfacts 2011(3): 0313-0313  
DOI: 10.1055/s-0030-1259423
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Boronic Acid and Trifluoroborate Synthesis from Aryl Chlorides

Contributor(s): Paul Knochel, Andreas K. Steib
G. A. Molander*, S. L. J. Trice, S. D. Dreher
University of Pennsylvania, Philadelphia and Merck Research Laboratories, Rahway, USA
Further Information

Publication History

Publication Date:
16 February 2011 (online)


A direct synthesis of boronic acids via palladium-catalyzed cross-coupling of aryl ­chlorides with tetrahydroxydiboron [B2(OH)4] is described. Additionally, the prepared arylboronic acids can be transformed into the corresponding trifluoroborates and boronic esters.