Palladium-Catalyzed Boronic Acid and Trifluoroborate Synthesis
from Aryl Chlorides

doi:10.1055/s-0030-1259423

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Synfacts 2011(3): 0313-0313
DOI: 10.1055/s-0030-1259423

Metal-Mediated Synthesis

Palladium-Catalyzed Boronic Acid and Trifluoroborate Synthesis from Aryl Chlorides

Contributor(s): Paul Knochel, Andreas K. Steib
G. A. Molander*, S. L. J. Trice, S. D. Dreher
University of Pennsylvania, Philadelphia and Merck Research Laboratories, Rahway, USA

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Publikationsverlauf

Publikationsdatum:
16. Februar 2011 (online)

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Significance

A direct synthesis of boronic acids via palladium-catalyzed cross-coupling of aryl chlorides with tetrahydroxydiboron [B₂(OH)₄] is described. Additionally, the prepared arylboronic acids can be transformed into the corresponding trifluoroborates and boronic esters.