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Palladium-Catalyzed Boronic Acid and Trifluoroborate Synthesis from Aryl Chlorides
G. A. Molander*, S. L. J. Trice, S. D. Dreher
University of Pennsylvania, Philadelphia and Merck Research Laboratories, Rahway, USA
16 February 2011 (online)
A direct synthesis of boronic acids via palladium-catalyzed cross-coupling of aryl chlorides with tetrahydroxydiboron [B2(OH)4] is described. Additionally, the prepared arylboronic acids can be transformed into the corresponding trifluoroborates and boronic esters.