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A New Route to Thieno[3,2-b]quinolines via an Original Heterocycle
M. J. Haddadin*, C. El-Nachef, H. Kisserwani, Y. Chaaban, M. J. Kurth*, J. C. Fettinger
American University of Beirut, Lebanon and University of California, Davis, USA
16 February 2011 (online)
The authors report a synthesis for thieno[3,2-b]quinolines 4 that is as easy as it is novel. The two-step, one-pot procedure gives the desired product in considerably better yield than the two previously reported syntheses of similar substrates. Additionally, compound 4 is accessed via a remarkable rearrangement of 3, the first reported cyclobutanaphthalene system containing two heteroatoms.