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Selective Synthesis of Secondary Amines with Cu(OH)x/Al2O3
J. He, K. Yamaguchi, N. Mizuno*
The University of Tokyo, Japan
16 February 2011 (online)
Aluminum-supported copper hydroxide Cu(OH)x/Al2O3 catalyzed the N-alkylation of primary amines 1, urea, or NH3 with benzyl alcohols 2 in mesitylene to give the corresponding secondary amines in 70-98% GC yield (14 examples). The catalyst was recovered by simple filtration and reused without significant loss of activity for the formation of 3c (75 min, 75% GC yield).