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Synfacts 2011(3): 0277-0277
DOI: 10.1055/s-0030-1259478
DOI: 10.1055/s-0030-1259478
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York1,4-Rhodium-Silicon Shift in an Enantioselective Synthesis of Indanols
T. Seiser, N. Cramer*
ETH Zürich, Switzerland
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
16. Februar 2011 (online)

Significance
The tendency of rhodium and palladium catalysts to undergo 1,4-shifts from alkyl or vinyl to aryl positions is a well-documented phenomenon (see Review). In contrast to their earlier work (Angew. Chem. Int. Ed. 2009, 48, 6320), the authors describe a 1,4-rhodium-silicon shift. This strategy is superior to the rhodium-hydrogen shift in the sense that functionality is introduced at the alkyl position, which can be easily further modified.
Review: F. Shi, R. C. Larock Top. Curr. Chem. 2010, 292, 123-164.