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Design of a New Bisphosphine Ligand for Asymmetric Hydrogenation
K. Huang, X. Zhang, T. J. Emge, G. Hou, B. Cao, X. Zhang*
Rutgers, The State University of New Jersey, Piscataway and The Pennsylvania State University, University Park, USA
16 February 2011 (online)
The C 1-symmetric bisphosphine ligand shown above was designed to be electron-rich and rigid, bearing a three-quandrant hindered structure. The ligand synthesis began with commercially available 1,2-cyclohexanedicarboxylic acid and featured a highly diastereoselective lithiation step, avoiding costly chiral HPLC purification.