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Synfacts 2011(4): 0421-0421  
DOI: 10.1055/s-0030-1259608
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Direct Sulfoximination

Contributor(s): Paul Knochel, Thomas Kunz
M. Miyasaka, K. Hirano, T. Satoh, R. Kowalczyk, C. Holm*, M. Miura*
Osaka University, Japan and RWTH Aachen University, Germany
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Herein, the direct dehydrogenative sulfoximination of azoles and polyfluoroarenes is reported. This copper acetate catalyzed C-N coupling proceeds effectively at room temperature in air and affords a wide range of N-arylsulfoximines in excellent yield. With this protocol, a preactivation step, such as halogenation or the formation of a metalated species, is not necessary.