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Synfacts 2011(4): 0384-0384
DOI: 10.1055/s-0030-1259625
DOI: 10.1055/s-0030-1259625
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New YorkNew Precursor for Difluorocarbenes
F. Wang, W. Zhang, J. Zhu, H. Li, K.-W. Huang*, J. Hu*
Shanghai Institute of Organic Chemistry, P. R. of China and King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia
Further Information
Publication History
Publication Date:
18 March 2011 (online)
Significance
Developing new fluorination methods is of great interest in areas such as material science and pharmaceuticals. However, the existing fluoroalkylation reagents are usually generated from hazardous materials or under harsh conditions. The authors demonstrated that (chlorodifluoromethyl)trimethylsilane (TMSCF2Cl) can be used as the precursor for difluorocarbene (:CF2) under neutral and relatively mild conditions.