Synfacts 2011(4): 0361-0361  
DOI: 10.1055/s-0030-1259640
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Sintokamides A, B and E

Contributor(s): Steven V. Ley, Sean Newton
Z. Gu, A. Zakarian*
University of California at Santa Barbara, USA
Further Information

Publication History

Publication Date:
18 March 2011 (online)


Sintokamides A-E were isolated from the marine sponge Dysidea sp. and represent a rare class of halogenated natural products. Sintokamides B and E were synthesized using the trichloromethyl derivative of J and l-leucine methyl ester hydrochloride instead of J, respectively (not shown).