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Synfacts 2011(4): 0396-0396  
DOI: 10.1055/s-0030-1259644
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

[6+2] Cycloadditions between Cyclohepta-triene and Allenes

Contributor(s): Mark Lautens, Stephen G. Newman
H. Clavier*, K. Le Jeune, I. de Riggi, A. Tenaglia*, G. Buono*
Université Aix-Marseille, France
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Transition-metal-mediated cyclo­additions are a highly efficient family of reactions for accessing medium-sized rings. Cyclohepta­triene is a common 6π component, capable of ­reacting with various 2π partners. Based on previous work with cobalt-mediated cycloadditions with alkynes (M. Achard, A. Tenaglia, G. Buono Org. Lett. 2005, 7, 2353), the authors present a stereoselective [6+2] cycloaddition between cycloheptatriene and allenes.