Synfacts 2011(4): 0413-0413  
DOI: 10.1055/s-0030-1259645
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Mukaiyama Aldol Reactions with Glyoxylates

Contributor(s): Mark Lautens, Stephen G. Newman
J.-F. Zhao, B.-H. Tan, T.-P. Loh*
Nanyang Technological University, Singapore
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Publikationsverlauf

Publikationsdatum:
18. März 2011 (online)

Significance

The enantioselective aldol reaction is among the most useful and well-developed transformations for the synthesis of chiral materials. Despite this, gaps in asymmetric aldol methodology still exist. The authors present the first ­example of a general, highly enantioselective ­Mukaiyama aldol reaction between aryl ketones and glyoxylates. An indium-PyBox complex is used as a chiral Lewis acid to induce asymmetry.