Subscribe to RSS
Desymmetrization of 2,2-Disubstituted
J. Y. Lee, Y. S. You, S. H. Kang*
Korea Advanced Institute of Science and Technology, Daejeon, Korea
18 March 2011 (online)
Using enantioselective desymmetrization protocols to prepare enantiomerically enriched molecules starting from symmetrical precursors is a very economic approach to generate chirality. However, the formation of quaternary stereogenic centers remains a challenging task. Herein, the authors present an asymmetric monobenzylation of readily available 2,2-disubstituted 1,3-diols of type 1 using a catalyst formed from the chiral pyridinebisoxazoline (PyBox) ligand L* and CuCl2.