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Asymmetric Ene and Aldol Reactions of Isatins, Diketones, and Keto Esters
K. Aikawa, S. Mimura, Y. Numata, K. Mikami*
Tokyo Institute of Technology, Japan
18 March 2011 (online)
3-Hydroxy-2-oxindole derivatives, bearing chiral quaternary centers, are important scaffolds of biologically active molecules. The described method here allows for the effective construction of this type of compounds by chiral dicationic palladium complex catalyzed enantio-selective ene and aldol reaction with various isatin substrates. This process was also effective with various keto esters and diketone substrates.