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Synfacts 2011(7): 0765-0765  
DOI: 10.1055/s-0030-1260502
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Pyridine-Directed Aerobic Olefination of Unactivated sp³ C-H Sites

Contributor(s): Paul Knochel, Andreas K. Steib
K. J. Stowers, K. C. Fortner, M. S. Sanford*
University of Michigan, Ann Arbor, USA
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Publikationsdatum:
17. Juni 2011 (online)

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Significance

A new palladium/polyoxometalate-catalyzed aerobic olefination of unactivated sp³ C-H bonds has been developed. Nitrogen-containing heterocycles act as directing groups and the products undergo reversible intramolecular Michael addition to form bicyclic nitrogen-containing scaffolds.