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Synfacts 2011(7): 0757-0757  
DOI: 10.1055/s-0030-1260655
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Chloroamination of α,β-Unsaturated γ-Keto Esters and Chalcones

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
Y. Cai, X. Liu, J. Jiang, W. Chen, L. Lin, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publikationsverlauf

Publikationsdatum:
17. Juni 2011 (online)

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Significance

The authors stretch the use of their (S)-pipecolic acid derived N,N′-dioxide ligand to chloroamination of α,β-unsaturated γ-keto esters and chalcones. Direct aminohalogenation is extremely underdeveloped, and this paper intro­duces an efficient method to access this type of reaction.