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Synfacts 2011(9): 0965-0965  
DOI: 10.1055/s-0030-1260861
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Aluminum-Catalyzed Cyclohexanone Ring Expansion with α-Diazoacetates

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
T. Hashimoto, Y. Naganawa, K. Maruoka*
Kyoto University, Japan
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Publication History

Publication Date:
19 August 2011 (online)

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Significance

Chiral acid catalyzed ring expansion of cyclohexanones remains a challenging process, as cyclohexanones are not prochiral substrates. The authors report the successful ­development of an aluminum catalyst system to achieve highly enantioselective ring expansion of cyclohexanones with α-diazoacetates.