Synfacts 2011(9): 0999-0999  
DOI: 10.1055/s-0030-1260884
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Catalyzed 1H-Perfluoroalkane Arylation by Aryl Iodide

Contributor(s): Paul Knochel, Andreas K. Steib
I. Popov, S. Lindeman, O. Daugulis*
University of Houston and Marquette University, Milwaukee, USA
Further Information

Publication History

Publication Date:
19 August 2011 (online)


A new method for the arylation of readily available 1H-perfluoroalkanes has been disclosed. 1H-Perfluoroalkanes are deprotonated by TMP2Zn (TMP= 2,2,6,6-tetramethylpiperidyl), transmetalated with copper chloride and subsequently cross-coupled with various aryl iodides.