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Cu-Catalyzed 1H-Perfluoroalkane Arylation by Aryl Iodide
I. Popov, S. Lindeman, O. Daugulis*
University of Houston and Marquette University, Milwaukee, USA
19 August 2011 (online)
A new method for the arylation of readily available 1H-perfluoroalkanes has been disclosed. 1H-Perfluoroalkanes are deprotonated by TMP2Zn (TMP= 2,2,6,6-tetramethylpiperidyl), transmetalated with copper chloride and subsequently cross-coupled with various aryl iodides.