Download PDF
Synfacts 2011(9): 1025-1025  
DOI: 10.1055/s-0030-1260893
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki-Miyaura Coupling in Water Using an NHC-Pd Polymer

Contributor(s): Yasuhiro Uozumi, Takao Osako
B. Karimi*, P. F. Akhavan
Institute for Advanced Studies in Basic Sciences, Gava Zang, Iran
Further Information

Publication History

Publication Date:
19 August 2011 (online)

   Permissions and Reprints

Significance

A water-soluble NHC-Pd polymer 3 was prepared by the reaction of 1 with TEG-Br in the presence of NaH followed by treatment with Pd(OAc)2 (eq. 1). The NHC-Pd polymer 3 catalyzed the Suzuki-Miyaura coupling of aryl bromides or aryl chlorides with arylboronic acids in water to give the corresponding biaryls in 69-93% yield (21 examples, eq. 2).