Synfacts 2011(9): 0966-0966  
DOI: 10.1055/s-0030-1260908
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Asymmetric Synthesis of Unnatural Amino Acids

Contributor(s): Hisashi Yamamoto, Susumu Oda
P. Tosatti, A. J. Campbell, D. House, A. Nelson*, S. P. Marsden*
University of Leeds and GlaxoSmithKline, Stevenage, UK
Further Information

Publication History

Publication Date:
19 August 2011 (online)

Significance

The authors report the asymmetric synthesis of unnatural amino acids through asymmetric allylic substitution followed by a cross-­metathesis reaction. The sequential catalytic ­systems using Cu, Ru and Ir are all well controlled with high stereoselectivities and, thus, the method provides stereodivergent access to unnatural amino acids.