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Synthesis of a CRF-1 Receptor Antagonist
K. J. Hodgetts et al.*
Neurogen Corporation, Branford, USA
19 August 2011 (online)
Corticotropin releasing factor-1 (CRF-1) antagonists are potential antidepressants and anxiolytic agents. The target molecule is an orally active CRF-1 antagonist with good brain penetration, but further development was halted owing to its long half-life and potential to accumulate in adipose tissues.