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Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans
J. Wang, E. A. Crane, K. A. Scheidt*
Northwestern University, Evanston, USA
19 August 2011 (online)
The authors report a synthesis of spirooxindole pyrans through a Brønsted acid catalyzed Prins cyclization. The reaction is highly diastereoselective and the products comprise an important structural motif. Several reactions of the products are reported to yield a variety of interesting derivatives.