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Synfacts 2011(9): 0986-0986
DOI: 10.1055/s-0030-1261035
DOI: 10.1055/s-0030-1261035
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Controlling E/Z Selectivity in the Formation of Alkenyl Imines
Y. Fukumoto*, M. Hagihara, F. Kinashi, N. Chatani
Osaka University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. August 2011 (online)
![](https://www.thieme-connect.de/media/synfacts/201109/lookinside/thumbnails/10.1055-s-0030-1261035-1.jpg)
Significance
The transition-metal-catalyzed syn addition of reagents across alkynes is an excellent process to synthesize substituted alkenes with high levels of stereocontrol. In the present communication, the authors report a rhodium-catalyzed silylation of alkynes, followed by addition to isonitriles. Remarkably, both E- and Z-stereoisomers can be obtained by modifying the isocyanide.