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Z-Selective Ruthenium-Catalyzed Olefin Cross Metathesis
K. Endo, R. H. Grubbs*
California Institute of Technology, Pasadena, USA
19 August 2011 (online)
Olefin cross-metathesis has found widespread use in bench-scale and process chemistry as a reliable way of forming carbon-carbon double bonds (see Review below). With few exceptions, the more thermodynamically favored E-isomers are produced. The authors demonstrate that, by utilizing a novel chelated ruthenium catalyst, selectivity for the Z-isomer can be achieved.
Review: G. C. Vougioukalakis, R. H. Grubbs Chem. Rev. 2010, 110, 1746-1787.