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Synfacts 2011(10): 1096-1096  
DOI: 10.1055/s-0030-1261115
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Trapping of Oxonium Ylides with Michael Acceptors

Contributor(s): Mark Lautens, Hasnain A. Malik
X. Han, M. Gan, H. Qiu, J. Ji, X. Zhang, L. Jiang*, W. Hu*
East China Normal University, Shanghai, P. R. of China
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

Multicomponent reactions are a powerful means to generate high levels of molecular complexity from relatively simple and readily available starting materials. Transition-metal catalysis is especially useful for these types of processes and catalyst control has the ability to rapidly create chiral products from achiral reactants. The authors disclose a diastereoselective Rh-catalyzed multicomponent reaction for the synthesis of produce α-hydroxy esters.