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Synfacts 2011(10): 1098-1098  
DOI: 10.1055/s-0030-1261126
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Allylic Substitutions with Hydroxamic Acid Derivatives

Contributor(s): Hisashi Yamamoto, Dmitry L. Usanov
M. Gärtner, M. Jäkel, M. Achatz, C. Sonnenschein, O. Tverskoy, G. Helmchen*
Ruprecht-Karls-Universität Heidelberg, Germany
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

In this paper asymmetric Ir-catalyzed allylic amination reactions involving hydroxamic acid derivatives were accomplished with excellent regio- and enantioselectivities; the resulting products are of interest as precursors of N-hydroxy aza-sugars, antibiotics and peptidomimetics. Synthetic routes to tetrahydro-1,2-oxazines/piperidones were established.