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Synfacts 2011(10): 1048-1048
DOI: 10.1055/s-0030-1261142
DOI: 10.1055/s-0030-1261142
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (-)-Neodysiherbaine A
T. J. Donohoe*, P. C. M. Winship, M. R. Tatton, P. Szeto
University of Oxford and GlaxoSmithKline Research & Development Limited, Stevenage, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. September 2011 (online)
Significance
Neodysiherbaine A is an amino acid isolated from the Dysidea herbacea Micronesian sponge. It is a convulsant and an agonist for KA and AMPA glutamate receptors. Previous syntheses have involved inversion of hydroxyl groups on the sugar moiety, which is avoided here by starting from commercially available β-d-ribose tetraacetate.