Am J Perinatol 2011; 28(3): 233-240
DOI: 10.1055/s-0030-1268238
©Thieme Medical Publishers

Efficacy of Intravenous Tranexamic Acid in Reducing Blood Loss after Elective Cesarean Section: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Kemal Gungorduk1 , Gokhan Yıldırım2 , Osman Asıcıoğlu2 , Ozgu Celıkkol Gungorduk2 , Sinem Sudolmus2 , Cemal Ark2
  • 1Department of Obstetrics and Gynecology, Mardin Women and Children Hospital, Mardin, Turkey
  • 2Department of Obstetrics and Gynecology, Istanbul Bakirkoy Women and Children Hospital, Istanbul, Turkey
Further Information

Publication History

Publication Date:
26 October 2010 (online)

ABSTRACT

We sought to determine the efficacy and safety of tranexamic acid (TA) in reducing blood loss during elective cesarean section (CS). We performed a randomized, double-blind, placebo-controlled study of 660 women who underwent elective CS. The patients were randomly selected to receive an intravenous infusion of either TA (1 g/10 mL in 20 mL of 5% glucose; n = 330) or 30 mL 5% glucose prior to surgery. The primary outcome was the estimated blood loss following CS. No demographic difference was observed between groups. The mean estimated blood loss was significantly lower in women treated with TA compared with women in the placebo group (499.9 ± 206.4 mL versus 600.7 ± 215.7 mL, respectively; p < 0.001), and the proportion of women in the TA group who had an estimated blood loss >1000 mL was significantly lower than in the placebo group (7 [2.1%] versus 19 [5.8%], respectively; relative risk [RR] 2.7; 95% confidence interval [CI] 1.1 to 6.3; p < 0.03). Furthermore, more women in the placebo group than in the TA group required additional uterotonic agents (48 [14.5%] versus 28 [8.5%], respectively; RR 1.7; 95% CI 1.1 to 2.6; p = 0.02). Maternal and neonatal outcomes did not differ significantly. TA significantly reduced bleeding during CS, the percentage of patients with blood loss >1000 mL, and the need for additional uterotonic agents. Furthermore, the incidence of thromboembolic events did not increase. Our results suggest that TA can be used safely and effectively to reduce CS bleeding.

REFERENCES

Kemal Gungorduk, M.D. 

Department of Obstetrics and Gynecology

Mardin Women and Children Hospital, Mardin, Turkey

Email: [email protected]