Zusammenfassung
Hintergrund: Es war Ziel dieser Analyse klinische Daten zur Effektivität und zu Komplikationen
der Verwendung schwerer Endotamponaden (F6H8®, Oxane HD®, Densiron 68®) bei komplizierten
Netzhautablösungen zu vergleichen. Methoden: Analysiert wurden alle in Medline gelisteten Arbeiten mit mindestens 10 behandelten
Augen und eigene Resultate aus vier institutionellen Fallserien. Ergebnisse: Die Verwendung jeder der drei Endotamponademedien resultierte zu einem hohen Prozentsatz
in einer erfolgreichen Netzhautanlage. Das Nebenwirkungsspektrum wies im Studienvergleich
eine beträchtliche Variationsbreite auf. F6H8® führte in einem relativ hohen Prozentsatz
zur Emulsifikation und war im Langzeitverlauf mit einem hohen Risiko der Entwicklung
chronischer Hypotonien verbunden. Mit Oxane HD® endotamponierte Augen entwickelten
relativ häufig eine klinisch signifikante entzündliche Reaktionen und sekundäre Membranen.
Bei Densiron 68® kam es häufig zur Emulsifikation. Schlussfolgerungen: Die Heterogenität der vorhandenen Studien erlaubt keinen definitiven Vergleich der
Endtamponademedien. Das verfügbare Datenmaterial lässt anscheinend Vorteile von Densiron
68® gegenüber den anderen schweren Endotamponaden hinsichtlich gravierender Nebenwirkungen
erkennen. Vor dem Hintergrund relativ hoher Komplikationsraten schwerer Endotamponaden
erscheint es ratsam, konventionelles „leichtes” Silikon als Mittel der ersten Wahl
zu betrachten, sofern eine Silikonendotampanode angezeigt und ein Gravitationseffekt
in den unteren Quadranten nicht erforderlich ist.
Abstract
Purpose: The aim of this review was to compare clinical data on the efficacy and complications
of heavier-than-water internal tamponades (F6 H8®, Oxane HD®, Densiron 68®) used in
eyes with complicated retinal detachments. Methods: An analysis was made of all case series with at least 10 eyes treated and cited in
Medline together with results of 4 own institutional case series. Results: Short-term internal tamponade with each of the mentioned substances led to successful
anatomic results in a relatively high percentage of eyes. The spectrum of complications
presented a considerable variation among studies. Data indicate the following trends:
F 6 H8® was reported to develop emulsification in a relatively high percentage of
treated cases and was reported to be related with a high risk of long-term chronic
hypotony. Eyes with Oxane HD® presented a relatively high rate of clinically significant
inflammatory reactions and secondary membrane formation. Use of Densiron 68® was relatively
frequently associated with emulsification. Conclusion: The heterogeneity of available clinical data does not allow a definitive comparison
of the 3 heavier-than-water endotampondes. The data so far available seem to indicate
as a trend that Densiron 68 may provide advantages compared to other substances concerning
the relative incidence of severe complications. On the background of relatively high
rates of heavy silicone complications it seems reasonable to regard conventional ”light”
silicones as first choice if a silicone endotamponade is desired and no need for a
gravity effect of the endotamponade is indicated.
Schlüsselwörter
schwere Endotamponade - Endotamponade - schweres Silikon - Densiron - Oxane HD - F6
H8 - Perfluorhexyloctane - Netzhaut - Ablatio retinae - proliferative Vitreoretinopathie
Key words
heavy internal tamponade - endotamponade - heavy silicone - Densiron - Oxane HD -
F6 H8 - perfluorohexyloctane - retina - retinal detachment - proliferative vitreoretinopathy
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1 Several case series were not cited in this review because it was obvious or very
probable by data comparison that patients mentioned there were subject of otherwise
published reports (double publication or even triple publication). This applies to
the following publications: Schatz et al. 2001, Spektrum Augenheilk; Sandner et al.
2006 & 2007, Romano et al. 2008, Graefes Arch Clin Exp Ophthalmol; Li et al. 2010,
Ophthalmologica; Stappler et al. 2009, Ophthalmologe.
2 The term ”emulsification” is used here according to the convention in ophthalmological
literature. The authors are aware that this does not comply with the precise scientific
definition. The same applies to the description of silicone as ”oil”.
3 Pagot-Mathis et al. (2006) not listed since treatment consisted of two different
silicones and results were not conclusive with respect to these different preparations.
Prof. Dr. Heinrich Gerding, FEBO
Department of Retinology
Klinik Pallas
Louis Giroud-Str. 20
4600 Olten
Switzerland
Phone: ++ 41/62/2 86 62 09
Fax: ++ 41/62/2 86 62 20
Email: hgerding@klinik-pallas.ch