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Synlett 2011(19): 2761-2765  
DOI: 10.1055/s-0031-1289871
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© Georg Thieme Verlag Stuttgart ˙ New York

Construction of Enantioenriched Tertiary Stereogenic Centers by Nickel- and Palladium-Catalyzed Cross-Coupling Reactions of Alkyl Electrophiles

Buck L. H. Taylor, Elizabeth R. Jarvo*
Natural Sciences I 4114, Department of Chemistry, University of California, Irvine, CA 92697, USA
Fax: +1(949)8248571; e-Mail: erjarvo@uci.edu;
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Publication History

Received 11 July 2011
Publication Date:
11 November 2011 (online)

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Abstract

Nickel and palladium catalysts have been developed for the cross-coupling of many challenging secondary alkyl electrophiles. Recent progress in this area is reviewed with emphasis on the control of stereochemistry in the formation of tertiary stereocenters. Stereoconvergent methods are discussed and recent alternative stereospecific approaches are highlighted.

Key words

nickel - palladium - cross-coupling - asymmetric catalysis - stereoselective synthesis

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