The Use of Tertiary Alkylmagnesium Nucleophiles in Ni-Catalyzed Cross-Coupling Reactions

Amruta Joshi-Pangu; Mark R. Biscoe

doi:10.1055/s-0031-1290765

Synlett, Table of Contents

Synlett 2012; 23(8): 1103-1107
DOI: 10.1055/s-0031-1290765

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The Use of Tertiary Alkylmagnesium Nucleophiles in Ni-Catalyzed Cross-Coupling Reactions

Amruta Joshi-Pangu

Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA, Fax: +1(212)6506107 Email: mbiscoe@ccny.cuny.edu

,

Mark R. Biscoe*

Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA, Fax: +1(212)6506107 Email: mbiscoe@ccny.cuny.edu

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Abstract

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Abstract

Nickel-catalyzed cross-coupling reactions of unactivated tertiary alkyl nucleophiles and aryl bromides have been developed using N-heterocyclic carbene ligands. These processes are reviewed alongside earlier attempts to employ unactivated tertiary alkyl nucleophiles in cross-coupling reactions. Potential mechanisms for the transformations, and future challenges in this field are discussed.

Key words

nickel - cross-coupling - transition metals - homogeneous catalysis - Grignard reaction

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References

References and Notes
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