Am J Perinatol 2012; 29(02): 121-126
DOI: 10.1055/s-0031-1295652
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Human Milk Versus Formula Feeding Among Preterm Infants: Short-Term Outcomes

Ayala Maayan-Metzger
1   Department of Neonatology, The Edmond and Lili Safra Children’s Hospital, Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
,
Shirli Avivi
1   Department of Neonatology, The Edmond and Lili Safra Children’s Hospital, Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
,
Irit Schushan-Eisen
1   Department of Neonatology, The Edmond and Lili Safra Children’s Hospital, Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
,
Jacob Kuint
1   Department of Neonatology, The Edmond and Lili Safra Children’s Hospital, Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
› Author Affiliations
Further Information

Publication History

30 April 2011

01 August 2011

Publication Date:
17 November 2011 (online)

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Abstract

We evaluated short-term neonatal outcomes among preterm infants according to type of feeding administered (human milk or formula). Retrospective data were collected on 400 preterm infants at gestational age ≤32 weeks. Groups were chosen and compared according to feeding type. The premature infants who were fed human milk had lower gestational age and birth weight than those who were formula fed. Lower rates of necrotizing enterocolitis (NEC) were detected in the group of infants fed human milk (p = 0.044). Lower rates of retinopathy of prematurity (ROP) were detected in a subgroup of breast-fed infants born at 24 to 28 weeks’ gestational age, but the results did not reach statistical significance using univariate analysis (p = 0.06). Using multivariate analysis, however, ROP stage III among this subgroup was significantly lower (p = 0.022). No differences were recorded for other neonatal complications such as infections or for growth parameters. The advantage of human milk feeding, found mainly among preterm infants with respect to rates of NEC and ROP, supports efforts to encourage mothers to feed their infants human milk.