Synlett 2013; 24(2): 145-149
DOI: 10.1055/s-0032-1317714
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© Georg Thieme Verlag Stuttgart · New York

Expanding Structural Diversity; Removable and Manipulable Directing Groups for C–H Activation

Chengming Wang
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen, 518055, P. R. of China   Fax: +86(755)26033174   Email: huangyong@pkusz.edu.cn
,
Yong Huang*
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen, 518055, P. R. of China   Fax: +86(755)26033174   Email: huangyong@pkusz.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 12 September 2012

Accepted after revision: 07 November 2012

Publication Date:
04 December 2012 (online)

Abstract

The need to use a static directing group represents a ­major limitation for the emerging field of ortho-selective C–H ­activation and functionalization. Chemistry was recently developed that allowed partial removal or minor transformations for certain directing groups. Our recent work demonstrated that triazenes were a class of excellent directing groups for C–H activation/functionalization, and subsequent chemical manipulations generated key compounds with synthetic versatility.

 
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