Synlett 2013; 24(3): 343-346
DOI: 10.1055/s-0032-1318117
letter
© Georg Thieme Verlag Stuttgart · New York

Stereocontrolled Synthesis of 5′- and 6′-Epimeric Analogues of Muraymycin Nucleoside Antibiotics

Anatol P. Spork
University of Paderborn, Department of Chemistry, Warburger Str. 100, 33 098 Paderborn, Germany   Fax: +49(5251)603245   Email: [email protected]
,
Christian Ducho*
University of Paderborn, Department of Chemistry, Warburger Str. 100, 33 098 Paderborn, Germany   Fax: +49(5251)603245   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 30 October 2012

Accepted after revision: 07 January 2013

Publication Date:
23 January 2013 (online)


Abstract

Naturally occurring nucleoside antibiotics, for example, Streptomyces-produced muraymycins, represent a promising class of potential lead structures for the development of novel antimicrobial agents. The efficient preparation of muraymycin analogues is an essential prerequisite for detailed structure–activity relationship (SAR) studies, particularly with respect to the variation of the stereochemistry in a controlled manner. In this work, stereoselective syntheses of 5′- as well as 6′-epimers of muraymycins are reported. The obtained target structures also represent useful probes for the elucidation of the biosynthesis of muraymycins and related nucleoside antibiotics.

Supporting Information

 
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