Synlett 2013; 24(8): 893-897
DOI: 10.1055/s-0032-1318493
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© Georg Thieme Verlag Stuttgart · New York

Synthesis of Nucleic Acid Polymers with Non-Canonical Nucleobases

Dennis Gillingham*
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland   Fax: +41(61)2670976   Email: dennis.gillingham@unibas.ch
,
Kiril Tishinov
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland   Fax: +41(61)2670976   Email: dennis.gillingham@unibas.ch
› Author Affiliations
Further Information

Publication History

Received: 25 January 2013

Accepted after revision: 04 March 2013

Publication Date:
19 March 2013 (online)

Abstract

Understanding and controlling the biology of nucleic acids is partially a challenge in synthetic chemistry: How to selectively manipulate a single subunit in a repeating polymer of near-identical units. Herein we examine approaches to tackle this synthetic challenge and highlight a recent contribution from our group that offers an efficient convergent method based on organometallic catalysis.

 
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