Am J Perinatol 2013; 30(06): 513-518
DOI: 10.1055/s-0032-1329182
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Resistin—A Novel Feature in the Diagnosis of Sepsis in Premature Neonates

Zeynel Gokmen
1   Division of Neonatology, Department of Pediatrics, Baskent Univesity, Ankara, Turkey
Servet Ozkiraz
1   Division of Neonatology, Department of Pediatrics, Baskent Univesity, Ankara, Turkey
Sevsen Kulaksizoglu
2   Department of Biochemistry, Baskent University, Ankara, Turkey
Hasan Kilicdag
1   Division of Neonatology, Department of Pediatrics, Baskent Univesity, Ankara, Turkey
Deniz Ozel
3   Department of Biostatistics and Medical Informatics, Akdeniz University, Antalya, Turkey
Ayse Ecevit
1   Division of Neonatology, Department of Pediatrics, Baskent Univesity, Ankara, Turkey
Aylin Tarcan
1   Division of Neonatology, Department of Pediatrics, Baskent Univesity, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

20 February 2012

23 July 2012

Publication Date:
12 November 2012 (online)


Objective To evaluate the diagnostic potential of resistin in sepsis and to compare results with C-reactive protein (CRP) in infants < 32 weeks of gestation.

Study Design A total of 64 infants were prospectively included in the study. Blood samples were collected for basal CRP and resistin within the first hour of life. When sepsis was suspected, samples were collected for CRP and resistin before the treatment was started (pretreatment CRP and resistin). On the third day of sepsis, CRP and resistin levels were measured for evaluating the treatment response (follow-up CRP and follow-up resistin). Culture-proven septic patients were divided into groups according to early or late-onset sepsis (EOS and LOS) and gram-negative or gram-positive sepsis (GNS and GPS).

Results Pretreatment and follow-up resistin levels were significantly higher than basal resistin levels in both EOS and LOS groups (p < 0.01), with a positive correlation with CRP levels. To predict the GNS and GPS area under curve, values of pretreatment CRP and resistin were 0.714 and 0.984, respectively (p = 0.039).

Conclusion Resistin had a superior potential to that of CRP in the diagnosis of sepsis in preterm infants. Resistin may be used as an early marker for sepsis in premature infants.

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