Synlett 2013; 24(12): 1459-1463
DOI: 10.1055/s-0033-1338841
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© Georg Thieme Verlag Stuttgart · New York

Enantioselective Functionalization of Terminal Alkynes by Gold Catalysis

Asmaa Kamal Mourad
a  Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany   Fax: +49(30)83853625   Email: cczekeli@chemie.fu-berlin.de
b  Fayoum University, University Zone, Fayoum, 63514, Egypt
,
Constantin Czekelius*
a  Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany   Fax: +49(30)83853625   Email: cczekeli@chemie.fu-berlin.de
› Author Affiliations
Further Information

Publication History

Received: 25 March 2013

Accepted after revision: 18 April 2013

Publication Date:
10 June 2013 (online)

Abstract

The enantioselective functionalization of alkynes is still a challenge in the field of gold catalysis. This article describes recent progress in the application of gold complexes with optically active ligands or counteranions for activation of alkynes towards nucleophiles, including the recently reported desymmetrization of terminal diynes.

 
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