Efficient and Stereoselective Nitration of Olefins with AgNO₂ and TEMPO

Abstract

Synthetic utility of nitroolefins in fundamental organic synthesis has inspired us to develop a method to access nitroolefins stereoselectively starting from olefins. Silver nitrite along with catalytic TEMPO was found to be the reagent combination of choice. The method enjoys a broad scope and functional-group tolerance while nitroolefins are obtained in high yields with excellent E-selectivity.

Key words

nitroolefin - stereoselective - olefin - nitration - high yields

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