Synthesis, Antimicrobial Evaluation and QSAR Studies of 2-hydroxy Propanoic Acid Derivatives

Abstract

A series of 2-hydroxypropanoic acid derivatives (1–26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMIC_am values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier’s valance second order molecular connectivity index (²χ^v) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives.

Key words

antibacterial - antifungal - synthesis - QSAR

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