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Drug Res (Stuttg) 2014; 64(05): 240-245
DOI: 10.1055/s-0033-1357127
DOI: 10.1055/s-0033-1357127
Original Article
Synthesis, Antimicrobial Evaluation and QSAR Studies of 2-hydroxy Propanoic Acid Derivatives
Authors
Further Information
Publication History
received 11 August 2013
accepted 07 September 2013
Publication Date:
08 October 2013 (online)
Abstract
A series of 2-hydroxypropanoic acid derivatives (1–26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMICam values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier’s valance second order molecular connectivity index (2χv) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives.
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