Synlett 2015; 26(10): 1283-1288
DOI: 10.1055/s-0034-1380412
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© Georg Thieme Verlag Stuttgart · New York

Recent Advances in the Synthesis of 2-Substituted Oxetanes

Owen A. Davis
Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK   Email: j.bull@imperial.ac.uk
,
James A. Bull*
Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK   Email: j.bull@imperial.ac.uk
› Author Affiliations
Further Information

Publication History

Received: 22 January 2015

Accepted after revision: 12 February 2015

Publication Date:
16 March 2015 (online)

Abstract

Recent interest in oxetanes in medicinal chemistry and as synthetic intermediates has led to the development of a number of methods for the synthesis of more functionalized and highly substituted oxetane derivatives. Here we review cyclization approaches for the preparation of 2-substituted oxetanes. Methods involving C–O bond formation, as well as recently developed C–C bond forming cyclization strategies are highlighted.

 
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