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Am J Perinatol 2015; 32(10): 939-943
DOI: 10.1055/s-0034-1543988
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Continuous Positive Airway Pressure and the Burden of Care for Transient Tachypnea of the Neonate: Retrospective Cohort Study

Camilla Gizzi
1   Department of Pediatrics and Neonatology, “S. Giovanni Calibita” Fatebenefratelli Hospital, Rome, Italy
,
Roman Klifa
2   Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, “A. Beclere” Medical Centre, Paris, France
,
Maria Grazia Pattumelli
1   Department of Pediatrics and Neonatology, “S. Giovanni Calibita” Fatebenefratelli Hospital, Rome, Italy
,
Luca Massenzi
1   Department of Pediatrics and Neonatology, “S. Giovanni Calibita” Fatebenefratelli Hospital, Rome, Italy
,
Melanie Taveira
2   Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, “A. Beclere” Medical Centre, Paris, France
,
Shivani Shankar-Aguilera
2   Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, “A. Beclere” Medical Centre, Paris, France
,
Daniele De Luca
2   Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, “A. Beclere” Medical Centre, Paris, France
› Author Affiliations
Further Information

Publication History

14 October 2014

24 November 2014

Publication Date:
26 March 2015 (online)

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Abstract

Objectives Transient tachypnea of the neonate (TTN) is the commonest neonatal respiratory disorder. Given TTN physiopathology, continuous positive airway pressure (CPAP) could be indicated for its treatment, but no data are available. Our aim is to clarify if CPAP might reduce the TTN burden of care.

Design Retrospective multicenter cohort study enrolling 42 full-term TTN babies treated with CPAP and 40 with oxygen supplementation.

Results CPAP-treated infants show shorter intensive care unit stay (CPAP, 2.5 ± 2 vs. Oxygen, 4.4 ± 2.6 days; adjβ, −2.1 [95% confidence interval (CI): −3.1; −1]); p < 0.001) and lower maximal oxygen fraction (adjβ, −4.7 [95% CI: −7.7; −1.7]; p = 0.003). Air leak incidence was similar between the groups (adjOR, 0.36 [95% CI: 0.1; 1.1); p = 0.08). Patients' comfort as per EDIN score was also unchanged. Given the shorter length of intensive care, the use of CPAP for treating TTN would spare on average around 7,000 Euros/infant.

Conclusion CPAP seems a useful therapeutics for TTN, as it may reduce the burden of care without increasing air leaks or patients' discomfort.

Keywords

transient tachypnea - neonate - continuous positive airway pressure - NICU stay - burden of care
 

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