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J Pediatr Infect Dis 2006; 01(04): 195-203
DOI: 10.1055/s-0035-1557097
DOI: 10.1055/s-0035-1557097
Review Article
Toll-like receptors; integrate innate and adaptive immunity, promise innovative therapies
Verantwortlicher Herausgeber dieser Rubrik:
Weitere Informationen
Publikationsverlauf
21. August 2006
29. September 2006
Publikationsdatum:
28. Juli 2015 (online)
Abstract
Innate component of immunity is a skilful system that senses invading microbial pathogens and integrates to adaptive immunity by Toll-like receptors (TLRs). Another function of TLRs is to work in sterile inflammation to ligands derived from damaged cells, which are not usually present in the extracellular environment. Thus, TLRs have very important interferences in the pathogenesis of inflammatory and immune diseases. The discovery of TLRs has transformed our approach to immunology and related diseases.