Synlett 2015; 26(18): 2479-2484
DOI: 10.1055/s-0035-1560171
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© Georg Thieme Verlag Stuttgart · New York

Functional Group Tolerant Markovnikov-Selective Hydrofunctionalization of Unactivated Olefins Using a Cobalt Complex as Catalyst

Hiroki Shigehisa*
Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan   Email: cgehisa@musashino-u.ac.jp
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Further Information

Publication History

Received: 11 June 2015

Accepted: 21 July 2015

Publication Date:
25 August 2015 (online)

Abstract

Recent developments in the Markovnikov-selective hydrofunctionalization of unactivated olefins are presented. Our group found that the use of a cobalt complex, an N-fluoropyridinium salt, and a siloxane facilitates hydrofunctionalization with excellent functional group tolerance. Mechanistically, this catalysis involves both a carbon radical and a carbocationic intermediate.

 
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